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Systematic Reviews & Other Evidence Synthesis

Information about systematic reviews, meta-analyses, scoping reviews, rapid reviews, and other types of evidence synthesis research outside of the health sciences.

Traditional Literature Reviews vs. Systematic Reviews

One commonly used form of evidence synthesis is a systematic review. This table compares a traditional literature review with a systematic review:

  Traditional Literature Review Systematic Review
Review Question/Topic Topics may be broad in scope; the goal of the review may be to place one's own research within the existing body of knowledge, or to gather information that supports a particular viewpoint. Starts with a well-defined research question to be answered by the review. Reviews are conducted with the aim of finding all existing evidence in an unbiased, transparent, and reproducible way.
Searching for Studies Searches may be ad hoc and based on what the author is already familiar with. Searches are not exhaustive or fully comprehensive. Attempts are made to find all existing published and unpublished literature on the research question. The process is well-documented and reported.
Selecting Studies Clear reasons for why studies were included or excluded from the review are often lacking. Reasons for including or excluding studies are explicit and informed by the research question.
Assessing the Quality of Included Studies Study quality or potential biases in study design are often not considered. Risk of bias of individual studies and overall quality of the evidence, including sources of heterogeneity between study results, are systematically assessed.
Synthesizing Existing Research Conclusions are more qualitative and may not be based on study quality. Conclusions are based on quality of the studies and provide recommendations for practice or to address knowledge gaps.

Conducting a Systematic Review: Step by Step

Systematic reviews usually require a team of at least three researchers if not more. Once the authors and any additional support personnel are assembled, a systematic review typically will include the following steps :

  1. Develop a protocol.
  2. Draft your research question and your inclusion/exclusion criteria.
  3. Select databases for the search.
  4. Select grey literature sources.
  5. Write a search strategy.
  6. Register the protocol.
  7. Translate the search strategy.
  8. Manage sources and de-duplicate search results.
  9. Screen articles.
  10. Assess the risk of bias.
  11. Extract data.
  12. Synthesize, map, or describe the results.

The following tabs (also linked above) describe each evidence synthesis step in more detail, as well as provide resources and guidance.